Engineering T cell receptor fusion proteins using nonviral CRISPR/Cas9 genome editing for cancer immunotherapy

Engineering T cell receptor fusion proteins using nonviral CRISPR/Cas9 genome editing for cancer immunotherapy

Abstract Manufacture of chimeric antigen receptor (CAR)‐T cells usually involves the use of viral delivery systems to achieve high transgene expression. However, it can be costly and may result in random integration of the CAR into the genome, creating several disadvantages including variation in tr...

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Main Authors: Runzhe Shu (Author), Maree Hammett (Author), Vera Evtimov (Author), Aleta Pupovac (Author), Nhu‐Y Nguyen (Author), Rasa Islam (Author), Junli Zhuang (Author), Seyeong Lee (Author), Tae‐hun Kang (Author), Kyujun Lee (Author), Ian Nisbet (Author), Peter Hudson (Author), Jae Young Lee (Author), Richard Boyd (Author), Alan Trounson (Author)
Format: Book
Published: Wiley, 2023-11-01T00:00:00Z.
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