Metabolite Profiling of Dihydroartemisinin in Blood of Plasmodium-Infected and Healthy Mice Using UPLC-Q-TOF-MSE

• Main Authors: Yifan Zhao (Author), Peng Sun (Author), Yue Ma (Author), Xiaoqiang Chang (Author), Xingyu Chen (Author), Xin Ji (Author), Yue Bai (Author), Dong Zhang (Author), Lan Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dihydroartemisinin (DHA) and its' derivatives have been employed as the most powerful first-line drugs for malarial treatment for several decades. The metabolism of DHA has not been studied clearly. Previous reports were focused on the pharmacokinetics procedure of DHA in healthy rats. The meta...