Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of ob/ob Mice

• Main Authors: Neira Sáinz (Author), Amaia Rodríguez (Author), Victoria Catalán (Author), Sara Becerril (Author), Beatriz Ramírez (Author), Javier Gómez-Ambrosi (Author), Gema Frühbeck (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obese leptin-deficient ob/ob mice exhibit a low-grade chronic inflammation together with a low muscle mass. Our aim was to analyze the changes in muscle expression levels of genes related to oxidative stress and inflammatory responses in leptin deficiency and to identify the effect of in vivo leptin...