Development of Extended-Release Mini-Tablets Containing Metoprolol Supported by Design of Experiments and Physiologically Based Biopharmaceutics Modeling

• Main Authors: Michele Georges Issa (Author), Natalia Vieira de Souza (Author), Bruna Wenyi Chuang Jou (Author), Marcelo Dutra Duque (Author), Humberto Gomes Ferraz (Author)
• 格式: 圖書
• 出版: MDPI AG, 2022-04-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The development of extended-release dosage forms with adequate drug release is a challenge for pharmaceutical companies, mainly when the drug presents high solubility, as in Biopharmaceutics Classification System (BCS) class I. This study aimed to develop extended-release mini-tablets containing met...