Liquisolid pellets: A pharmaceutical technology strategy to improve the dissolution rate of ritonavir

• Main Authors: Brenda De Espíndola (Author), André O'Reilly Beringhs (Author), Diva Sonaglio (Author), Hellen Karine Stulzer (Author), Marcos Antônio Segatto Silva (Author), Humberto Gomes Ferraz (Author), Bianca Ramos Pezzini (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liquisolid pellets (LPs) prepared by extrusion-spheronization are promising delivery systems to improve the dissolution rate of poorly water-soluble drugs. However, developing LPs for high dose drugs (e.g. antiretroviral ritonavir, RTV) is a major challenge due to technical and quality constraints....