Inflammatory-miR-301a circuitry drives mTOR and Stat3-dependent PSC activation in chronic pancreatitis and PanIN

• Main Authors: Fugui Li (Author), Miaomiao Wang (Author), Xun Li (Author), Yihao Long (Author), Kaizhao Chen (Author), Xinjie Wang (Author), Mingtian Zhong (Author), Weimin Cheng (Author), Xuemei Tian (Author), Ping Wang (Author), Mingfang Ji (Author), Xiaodong Ma (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activated pancreatic stellate cells (PSCs) are the main cells involved in chronic pancreatitis and pancreatic intraepithelial neoplasia lesion (PanIN). Fine-tuning the precise molecular targets in PSC activation might help the development of PSC-specific therapeutic strategies to tackle progression...