Bioaccumulation and biotransformation of simvastatin in probiotic bacteria: A step towards better understanding of drug-bile acids-microbiome interactions

• Main Authors: Maja Đanić (Author), Nebojša Pavlović (Author), Slavica Lazarević (Author), Bojan Stanimirov (Author), Saša Vukmirović (Author), Hani Al-Salami (Author), Armin Mooranian (Author), Momir Mikov (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Although pharmacogenetics and pharmacogenomics have been at the forefront of research aimed at finding novel personalized therapies, the focus of research has recently extended to the potential of intestinal microbiota to affect drug efficacy. Complex interplay of gut microbiota with b...