NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment

• Main Authors: Shubham Rastogi (Author), Sara Aldosary (Author), Abdulaziz S. Saeedan (Author), Mohd. Nazam Ansari (Author), Manjari Singh (Author), Gaurav Kaithwas (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia is caused by a cancer-promoting milieu characterized by persistent inflammation. NF-κB and HIF-1α are critical participants in this transition. Tumor development and maintenance are aided by NF-κB, while cellular proliferation and adaptability to angiogenic signals are aided by HIF-1α. Proly...