An Effective and Safe Enkephalin Analog for Antinociception

• Main Authors: K. K. DurgaRao Viswanadham (Author), Roland Böttger (Author), Lukas Hohenwarter (Author), Anne Nguyen (Author), Elham Rouhollahi (Author), Alexander Smith (Author), Yi-Hsuan Tsai (Author), Yuan-Yu Chang (Author), Christopher Llynard Ortiz (Author), Lee-Wei Yang (Author), Liliana Jimenez (Author), Siyuan Li (Author), Chan Hur (Author), Shyh-Dar Li (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Opioids account for 69,000 overdose deaths per annum worldwide and cause serious side effects. Safer analgesics are urgently needed. The endogenous opioid peptide Leu-Enkephalin (Leu-ENK) is ineffective when introduced peripherally due to poor stability and limited membrane permeability. We develope...