Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue

• Main Authors: Marco Bauzá-Thorbrügge (Author), Elin Banke (Author), Belén Chanclón (Author), Eduard Peris (Author), Yanling Wu (Author), Saliha Musovic (Author), Cecilia Jönsson (Author), Peter Strålfors (Author), Patrik Rorsman (Author), Charlotta S. Olofsson (Author), Ingrid Wernstedt Asterholm (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) transports Ca2+ from the cytosol into the endoplasmic retitculum (ER) and is essential for appropriate regulation of intracellular Ca2+ homeostasis. The objective of this study was to test the hypothesis that SERCA pumps are involved in the...