Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Mitiglinide is a highly selective fast-acting anti-diabetic drug that induces insulin secretion by inhibiting pancreatic KATP channels. However, how mitiglinide binds KATP channels remains unknown. Here, we show the cryo-EM structure of the SUR1 subunit complexed with mitiglinide. The structure reve...
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Frontiers Media S.A.,
2022-06-01T00:00:00Z.
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