Suppression of the acute upregulation of phosphorylated-extracellular regulated kinase in ventral tegmental area by a μ-opioid receptor agonist is related to resistance to rewarding effects in a mouse model of bone cancer

Suppression of the acute upregulation of phosphorylated-extracellular regulated kinase in ventral tegmental area by a μ-opioid receptor agonist is related to resistance to rewarding effects in a mouse model of bone cancer

We investigated the mechanisms underlying the suppression of the rewarding effects of opioids using the femur bone cancer (FBC) mouse model. The rewarding and antinociceptive effects of subcutaneously administered morphine and oxycodone in the FBC model mice were assessed using the conditioned place...

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Main Authors: Atsushi Nakamura (Author), Hiroko Ono (Author), Azusa Ando (Author), Mikie Hinata (Author), Kazuki Niidome (Author), Shigeki Omachi (Author), Gaku Sakaguchi (Author), Shunji Shinohara (Author)
Format: Book
Published: Elsevier, 2017-01-01T00:00:00Z.
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3rd Floor Main Library

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