Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment

• Main Authors: Gufang Zhang (Author), Shuangshuang Chen (Author), Jia Jia (Author), Chun Liu (Author), Weipeng Wang (Author), Hongjian Zhang (Author), Xuechu Zhen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epidemiologic data reveal that diabetes patients taking metformin exhibit lower incidence of stroke and better functional outcomes during post-stroke neurologic recovery. We previously demonstrated that chronic post-ischemic administration of metformin improved functional recovery in experimental ce...