Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications

• Main Authors: Marta Llansola (Author), Yaiza M. Arenas (Author), María Sancho-Alonso (Author), Gergana Mincheva (Author), Andrea Palomares-Rodriguez (Author), Magnus Doverskog (Author), Paula Izquierdo-Altarejos (Author), Vicente Felipo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enhanced GABAergic neurotransmission contributes to impairment of motor coordination and gait and of cognitive function in different pathologies, including hyperammonemia and hepatic encephalopathy. Neuroinflammation is a main contributor to enhancement of GABAergic neurotransmission through increas...