A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide

• Main Authors: Jonathan M. Williams (Author), Carrie A. Duckworth (Author), Alastair J. M. Watson (Author), Mark R. Frey (Author), Jennifer C. Miguel (Author), Michael D. Burkitt (Author), Robert Sutton (Author), Kevin R. Hughes (Author), Lindsay J. Hall (Author), Jorge H. Caamaño (Author), Barry J. Campbell (Author), D. Mark Pritchard (Author)
• Format: Book
• Published: The Company of Biologists, 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The gut barrier, composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, prevents the entrance of harmful microorganisms, antigens and toxins from the gut lumen into the blood. Small intestinal homeostasis is normally maintained by the rate of shedd...