Improved dissolution and micromeritic properties of naproxen from spherical agglomerates: preparation, in vitro and in vivo characterization

• Main Authors: Damineni Saritha (Author), Penjuri Subhash Chandra Bose (Author), Poreddy Srikanth Reddy (Author), Grandhi Madhuri (Author), Ravouru Nagaraju (Author)
• Format: Book
• Published: Universidade de São Paulo, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Naproxen, an anti-inflammatory drug, exhibits poor aqueous solubility, which limits the pharmacological effects. The present work was carried out to study the effect of agglomeration on micromeritic properties and dissolution. Naproxen agglomerates were prepared by using a three solvents system comp...