Osteoking promotes bone formation and bone defect repair through ZBP1-STAT1-PKR-MLKL-mediated necroptosis

• Main Authors: Suya Zhang (Author), Yudong Liu (Author), Zhaochen Ma (Author), Shuangrong Gao (Author), Lin Chen (Author), Honggang Zhong (Author), Chu Zhang (Author), Tao Li (Author), Weiheng Chen (Author), Yanqiong Zhang (Author), Na Lin (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Osteoking has been used for fracture therapy with a satisfying clinical efficacy. However, its therapeutic properties and the underlying mechanisms remain elusive. Method A bone defect rat model was established to evaluate the pharmacological effects of Osteoking by the dynamic o...