mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice

• Main Authors: Alexander S. Ham (Author), Kathrin Chojnowska (Author), Lionel A. Tintignac (Author), Shuo Lin (Author), Alexander Schmidt (Author), Daniel J. Ham (Author), Michael Sinnreich (Author), Markus A. Rüegg (Author)
• Format: Book
• Published: Wiley, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the mammalian target of rapamycin complex 1 (mTORC1) regulates proteostasis in skeletal muscle by affecting protein synthesis and autophagosom...