Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.

• Главные авторы: Mathias Beig (Автор), Frank Oellien (Автор), Linnéa Garoff (Автор), Sandra Noack (Автор), R Luise Krauth-Siegel (Автор), Paul M Selzer (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Предметы: article
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With the goal to identify novel trypanothione reductase (TR) inhibitors, we performed a combination of in vitro and in silico screening approaches. Starting from a highly diverse compound set of 2,816 compounds, 21 novel TR inhibiting compounds could be identified in the initial in vitro screening c...