Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.

• Asıl Yazarlar: Mathias Beig (Yazar), Frank Oellien (Yazar), Linnéa Garoff (Yazar), Sandra Noack (Yazar), R Luise Krauth-Siegel (Yazar), Paul M Selzer (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

With the goal to identify novel trypanothione reductase (TR) inhibitors, we performed a combination of in vitro and in silico screening approaches. Starting from a highly diverse compound set of 2,816 compounds, 21 novel TR inhibiting compounds could be identified in the initial in vitro screening c...