Application of replication-defective West Nile virus vector to non-flavivirus vaccine targets

• Main Authors: Maryann Giel-Moloney (Author), Michael Vaine (Author), Linong Zhang (Author), Mark Parrington (Author), Beata Gajewska (Author), Thorsten U. Vogel (Author), Svetlana O. Pougatcheva (Author), Xiaochu Duan (Author), Timothy Farrell (Author), Irina Ustyugova (Author), Sanjay Phogat (Author), Harry Kleanthous (Author), Konstantin V. Pugachev (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The RepliVax vaccine platform(RV) is based on flavivirus genomes that are rationally attenuated by deletion. The self-limiting infection provided by RV has been demonstrated to be safe, highly immunogenic and efficacious for several vaccine candidates against flaviviruses. Here respiratory syncytial...