A brief history of the discovery of PXR and CAR as xenobiotic receptors
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998. Due to their activities in the transcriptional regulation of phase I and phase II enzymes as well as drug transporters, PXR and CAR have been def...
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Format: | Book |
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Elsevier,
2016-09-01T00:00:00Z.
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A1234.567 |
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