Validation of Liquid Chromatography Coupled with Tandem Mass Spectrometry for the Determination of 12 Tyrosine Kinase Inhibitors (TKIs) and Their Application to Therapeutic Drug Monitoring in Adult and Pediatric Populations

Validation of Liquid Chromatography Coupled with Tandem Mass Spectrometry for the Determination of 12 Tyrosine Kinase Inhibitors (TKIs) and Their Application to Therapeutic Drug Monitoring in Adult and Pediatric Populations

Tyrosine kinase inhibitors (TKIs) are used as targeted cancer therapies in adults and have an off-label pediatric application for the treatment of Langerhans cell histiocytosis. A multitarget LC-MS/MS method was developed and validated for the determination of alectinib, alectinib-M4, binimetinib, c...

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Main Authors: Marie Bellouard (Author), Jean Donadieu (Author), Pauline Thiebot (Author), Etienne Giroux Leprieur (Author), Philippe Saiag (Author), Isabelle Etting (Author), Pamela Dugues (Author), Emuri Abe (Author), Jean-Claude Alvarez (Author), Islam-Amine Larabi (Author)
Format: Book
Published: MDPI AG, 2023-12-01T00:00:00Z.
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