Validation of Liquid Chromatography Coupled with Tandem Mass Spectrometry for the Determination of 12 Tyrosine Kinase Inhibitors (TKIs) and Their Application to Therapeutic Drug Monitoring in Adult and Pediatric Populations

• Main Authors: Marie Bellouard (Author), Jean Donadieu (Author), Pauline Thiebot (Author), Etienne Giroux Leprieur (Author), Philippe Saiag (Author), Isabelle Etting (Author), Pamela Dugues (Author), Emuri Abe (Author), Jean-Claude Alvarez (Author), Islam-Amine Larabi (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tyrosine kinase inhibitors (TKIs) are used as targeted cancer therapies in adults and have an off-label pediatric application for the treatment of Langerhans cell histiocytosis. A multitarget LC-MS/MS method was developed and validated for the determination of alectinib, alectinib-M4, binimetinib, c...