Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

• मुख्य लेखकों: Ondrej Martinec (लेखक), Carin Biel (लेखक), Inge A. M. de Graaf (लेखक), Martin Huliciak (लेखक), Koert P. de Jong (लेखक), Frantisek Staud (लेखक), Filip Cecka (लेखक), Peter Olinga (लेखक), Ivan Vokral (लेखक), Lukas Cerveny (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug-drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon associated with significantly decreased drug bioavailabil...