Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

• Main Authors: Ondrej Martinec (Author), Carin Biel (Author), Inge A. M. de Graaf (Author), Martin Huliciak (Author), Koert P. de Jong (Author), Frantisek Staud (Author), Filip Cecka (Author), Peter Olinga (Author), Ivan Vokral (Author), Lukas Cerveny (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug-drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon associated with significantly decreased drug bioavailabil...