Application of machine learning to predict reduction in total PANSS score and enrich enrollment in schizophrenia clinical trials

• Main Authors: Jagdeep T. Podichetty (Author), Rebecca M. Silvola (Author), Violeta Rodriguez‐Romero (Author), Richard F. Bergstrom (Author), Majid Vakilynejad (Author), Robert R. Bies (Author), Robert E. Stratford Jr (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clinical trial efficiency, defined as facilitating patient enrollment, and reducing the time to reach safety and efficacy decision points, is a critical driving factor for making improvements in therapeutic development. The present work evaluated a machine learning (ML) approach to improve...