Absorption, Metabolism, and Excretion of ACT-1004-1239, a First-In-Class CXCR7 Antagonist: In Vitro, Preclinical, and Clinical Data

Absorption, Metabolism, and Excretion of ACT-1004-1239, a First-In-Class CXCR7 Antagonist: In Vitro, Preclinical, and Clinical Data

ACT-1004-1239 is a potent, selective, first-in-class CXCR7 antagonist, which shows a favorable preclinical and clinical profile. Here we report the metabolites and the metabolic pathways of ACT-1004-1239 identified using results from in vitro and in vivo studies. Two complementary in vitro studies (...

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Main Authors: Christine Huynh (Author), Swen Seeland (Author), Jerome Segrestaa (Author), Carmela Gnerre (Author), Jens Hogeback (Author), Henriette E. Meyer zu Schwabedissen (Author), Jasper Dingemanse (Author), Patricia N. Sidharta (Author)
Format: Book
Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
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