Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

• Main Authors: Yoichi Sunagawa (Author), Masafumi Funamoto (Author), Shogo Sono (Author), Kana Shimizu (Author), Satoshi Shimizu (Author), Mai Genpei (Author), Yusuke Miyazaki (Author), Yasufumi Katanasaka (Author), Eriko Morimoto (Author), Morio Ueno (Author), Maki Komiyama (Author), Hideaki Kakeya (Author), Hiromichi Wada (Author), Koji Hasegawa (Author), Tatsuya Morimoto (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other...