Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other...

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Main Authors: Yoichi Sunagawa (Author), Masafumi Funamoto (Author), Shogo Sono (Author), Kana Shimizu (Author), Satoshi Shimizu (Author), Mai Genpei (Author), Yusuke Miyazaki (Author), Yasufumi Katanasaka (Author), Eriko Morimoto (Author), Morio Ueno (Author), Maki Komiyama (Author), Hideaki Kakeya (Author), Hiromichi Wada (Author), Koji Hasegawa (Author), Tatsuya Morimoto (Author)
Format: Book
Published: Elsevier, 2018-04-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Yoichi Sunagawa  |e author 
700 1 0 |a Masafumi Funamoto  |e author 
700 1 0 |a Shogo Sono  |e author 
700 1 0 |a Kana Shimizu  |e author 
700 1 0 |a Satoshi Shimizu  |e author 
700 1 0 |a Mai Genpei  |e author 
700 1 0 |a Yusuke Miyazaki  |e author 
700 1 0 |a Yasufumi Katanasaka  |e author 
700 1 0 |a Eriko Morimoto  |e author 
700 1 0 |a Morio Ueno  |e author 
700 1 0 |a Maki Komiyama  |e author 
700 1 0 |a Hideaki Kakeya  |e author 
700 1 0 |a Hiromichi Wada  |e author 
700 1 0 |a Koji Hasegawa  |e author 
700 1 0 |a Tatsuya Morimoto  |e author 
245 0 0 |a Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes 
260 |b Elsevier,   |c 2018-04-01T00:00:00Z. 
500 |a 1347-8613 
500 |a 10.1016/j.jphs.2017.12.013 
520 |a The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other major curcuminoids isolated from Curcuma longa including demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are structural analogs of CUR. In present study, we first confirmed the effect of these three curcuminoid analogs on p300-HAT activity and cardiomyocyte hypertrophy.Our results showed that DMC and BDMC inhibited p300-HAT activity and cardiomyocyte hypertrophy to almost the same extent as CUR. As the three compounds have structural differences in methoxy groups at the 3-position of their phenol rings, our results suggest that these methoxy groups are not involved in the inhibitory effects on p300-HAT activity and cardiac hypertrophy. These findings provide useful insights into the structure-activity relationship and biological activity of curcuminoids for p300-HAT activity and cardiomyocyte hypertrophy. Keywords: Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin, p300, Cardiomyocyte hypertrophy 
546 |a EN 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Journal of Pharmacological Sciences, Vol 136, Iss 4, Pp 212-217 (2018) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S1347861318300446 
787 0 |n https://doaj.org/toc/1347-8613 
856 4 1 |u https://doaj.org/article/466bb888092b41d9b00f70db1ef7f77c  |z Connect to this object online.