A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth

• Main Authors: Uttara Saran (Author), Balaji Chandrasekaran (Author), Ashish Tyagi (Author), Vaibhav Shukla (Author), Amandeep Singh (Author), Arun K. Sharma (Author), Chendil Damodaran (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although breast cancer stem cells (BCSCs) are well characterized, molecularly targeting and eradicating this sub-population remains a challenge in the clinic. Recent studies have explored several signaling pathways that govern stem cell activation: We and others established that the Notch1 signaling...