Characteristics of Skin Deposition of Itraconazole Solubilized in Cream Formulation

• Main Authors: Hyeongmin Kim (Author), Sukkyun Jung (Author), Sooho Yeo (Author), Dohyun Kim (Author), Young Chae Na (Author), Gyiae Yun (Author), Jaehwi Lee (Author)
• Format: Book
• Published: MDPI AG, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Itraconazole (ITZ) is an anti-fungal agent generally used to treat cutaneous mycoses. For efficient delivery of ITZ to the skin tissues, an oil-in-water (O/W) cream formulation was developed. The O/W cream base was designed based on the solubility measurement of ITZ in various excipients. A physical...