Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction

• Main Authors: Yasuharu Shinoda (Author), Hideaki Tagashira (Author), Md. Shenuarin Bhuiyan (Author), Hideyuki Hasegawa (Author), Hiroshi Kanai (Author), Kohji Fukunaga (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Haloperidol is an antipsychotic drug that inhibits the dopamine D2 receptor among others. Haloperidol also binds the sigma-1 receptor (σ1R) and inhibits it irreversibly. A serious outcome of haloperidol treatment of schizophrenia patients is death due to sudden cardiac failure. Although the cause re...