Obeticholic acid and ferrostatin-1 differentially ameliorate non-alcoholic steatohepatitis in AMLN diet-fed ob/ob mice

• Auteurs principaux: Shengjie Li (Auteur), Aoxiang Zhuge (Auteur), Kaicen Wang (Auteur), Jiafeng Xia (Auteur), Qiangqiang Wang (Auteur), Shengyi Han (Auteur), Jian Shen (Auteur), Lanjuan Li (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Introduction: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common chronic liver diseases with limited treatment options.Methods: Ob/ob mice (6 weeks old) were fed with the Control diet or amylin liver NASH (AMLN) diet for 24 weeks to establish the NASH, the...