Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

• Main Authors: Zhiqiang Chen (Author), Yueming Qian (Author), Yuanli Song (Author), Xuankuo Xu (Author), Li Tao (Author), Nesredin Mussa (Author), Sanchayita Ghose (Author), Zheng Jian Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery. Despite the success of protein engineering in improving antibody biophysical properties, a clear gap still exists betwee...