The silencing effect of miR-30a on ITGA4 gene expression in vitro: an approach for gene therapy

• Main Authors: Leila Darzi (Author), Maryam Boshtam (Author), Laleh Shariati (Author), Shirin Kouhpayeh (Author), Azam Gheibi (Author), Mina Mirian (Author), Ilnaz Rahimmanesh (Author), Hossein Khanahmad (Author), Mohammad Amin Tabatabaiefar (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Integrins are adhesion molecules which play crucial roles in cell-cell and cell-extracellular matrix interactions. Very late antigen-4 or α4β1 and lymphocyte Peyer's patch adhesion molecule-1 or α4β7, are key factors in the invasion of tumor cells and metastasis. Based on the previous reports,...