Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays

• Main Authors: Elena Abbotto (Author), Beatrice Casini (Author), Francesco Piacente (Author), Naomi Scarano (Author), Elena Cerri (Author), Michele Tonelli (Author), Cecilia Astigiano (Author), Enrico Millo (Author), Laura Sturla (Author), Santina Bruzzone (Author), Elena Cichero (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining attention for the treatment of different cancer types, but also to contrast neurodegenerative disease, diabetes, and autoimmune syndromes. In the search for SIRT2 modulators, the availability of several X-crysta...