Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays

• المؤلفون الرئيسيون: Elena Abbotto (مؤلف), Beatrice Casini (مؤلف), Francesco Piacente (مؤلف), Naomi Scarano (مؤلف), Elena Cerri (مؤلف), Michele Tonelli (مؤلف), Cecilia Astigiano (مؤلف), Enrico Millo (مؤلف), Laura Sturla (مؤلف), Santina Bruzzone (مؤلف), Elena Cichero (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2023-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining attention for the treatment of different cancer types, but also to contrast neurodegenerative disease, diabetes, and autoimmune syndromes. In the search for SIRT2 modulators, the availability of several X-crysta...