The Solubility Studies and the Complexation Mechanism Investigations of Biologically Active Spiro[cyclopropane-1,3'-oxindoles] with β-Cyclodextrins

• Main Authors: Anna A. Kravtsova (Author), Anna A. Skuredina (Author), Alexander S. Malyshev (Author), Irina M. Le-Deygen (Author), Elena V. Kudryashova (Author), Ekaterina M. Budynina (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2023-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

In this work, we first improved the aqueous solubility of biologically active spiro[cyclopropane-1,3'-oxindoles] (SCOs) via their complexation with different β-cyclodextrins (β-CDs) and proposed a possible mechanism of the complex formation. β-CDs significantly increased the water solubility of...