Programming of cardiac metabolism by miR-15b-5p, a miRNA released in cardiac extracellular vesicles following ischemia-reperfusion injury

• Main Authors: Lucas C. Pantaleão (Author), Elena Loche (Author), Denise S. Fernandez-Twinn (Author), Laura Dearden (Author), Adriana Córdova-Casanova (Author), Clive Osmond (Author), Minna K. Salonen (Author), Eero Kajantie (Author), Youguo Niu (Author), Juliana de Almeida-Faria (Author), Benjamin D. Thackray (Author), Tuija M. Mikkola (Author), Dino A. Giussani (Author), Andrew J. Murray (Author), Martin Bushell (Author), Johan G. Eriksson (Author), Susan E. Ozanne (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: We investigated the potential involvement of miRNAs in the developmental programming of cardiovascular diseases (CVD) by maternal obesity. Methods: Serum miRNAs were measured in individuals from the Helsinki Birth Cohort (with known maternal body mass index), and a mouse model was used to...