Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

• Egile Nagusiak: A.T. Pettersson-Klein (Egilea), M. Izadi (Egilea), D.M.S. Ferreira (Egilea), I. Cervenka (Egilea), J.C. Correia (Egilea), V. Martinez-Redondo (Egilea), M. Southern (Egilea), M. Cameron (Egilea), T. Kamenecka (Egilea), L.Z. Agudelo (Egilea), M. Porsmyr-Palmertz (Egilea), U. Martens (Egilea), B. Lundgren (Egilea), M. Otrocka (Egilea), A. Jenmalm-Jensen (Egilea), P.R. Griffin (Egilea), J.L. Ruas (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2018-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: The peroxisome proliferator-activated receptor-γ coactivator-1α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy expenditure through PGC-1α1 activation is potentially beneficial for systemic metabolism. Pharmacological PGC-1α1 activators could be...