Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

• Main Authors: A.T. Pettersson-Klein (Author), M. Izadi (Author), D.M.S. Ferreira (Author), I. Cervenka (Author), J.C. Correia (Author), V. Martinez-Redondo (Author), M. Southern (Author), M. Cameron (Author), T. Kamenecka (Author), L.Z. Agudelo (Author), M. Porsmyr-Palmertz (Author), U. Martens (Author), B. Lundgren (Author), M. Otrocka (Author), A. Jenmalm-Jensen (Author), P.R. Griffin (Author), J.L. Ruas (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The peroxisome proliferator-activated receptor-γ coactivator-1α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy expenditure through PGC-1α1 activation is potentially beneficial for systemic metabolism. Pharmacological PGC-1α1 activators could be...