New Approaches to Blockade of the Renin-Angiotensin-Aldosterone System: Characteristics and Usefulness of the Direct Renin Inhibitor Aliskiren

• Main Authors: Atsuhiro Ichihara (Author), Mariyo Sakoda (Author), Asako Kurauchi-Mito (Author), Tatsuya Narita (Author), Kenichiro Kinouchi (Author), Kanako Bokuda (Author), Hiroshi Itoh (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since renin inhibition interferes with the first and rate-limiting steps in the renin-angiotensin system, the renin step is a very attractive target for lowering blood pressure and minimizing target-organ damage. The newly developed direct renin inhibitor aliskiren has several attractive characteris...