Exposure-response modeling for nausea incidence for cotadutide using a Markov modeling approach

• Main Authors: Hongtao Yu (Author), Sebastian Ueckert (Author), Lina Zhou (Author), Jenny Cheng (Author), Darren Robertson (Author), Lars Hansen (Author), Armando Flor (Author), Victoria Parker (Author), Bengt Hamrén (Author), Anis A. Khan (Author)
• Format: Book
• Published: Wiley, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cotadutide is a dual glucagon‐like peptide‐1 (GLP‐1)/glucagon receptor agonist. Gastrointestinal adverse effects are known to be associated with GLP‐1 receptor agonism and can be mitigated through tolerance development via a gradual up‐titration. This analysis aimed to characterize the rela...