Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4

• Main Authors: Mohamed Albadry (Author), Jonas Küttner (Author), Jan Grzegorzewski (Author), Olaf Dirsch (Author), Eva Kindler (Author), Robert Klopfleisch (Author), Vaclav Liska (Author), Vladimira Moulisova (Author), Sandra Nickel (Author), Richard Palek (Author), Jachym Rosendorf (Author), Sylvia Saalfeld (Author), Utz Settmacher (Author), Hans-Michael Tautenhahn (Author), Matthias König (Author), Uta Dahmen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is a lack of systematic research exploring cross-species variation in liver lobular geometry and zonation patterns of critical drug-metabolizing enzymes, a knowledge gap essential for translational studies. This study investigated the critical interplay between lobular geometry and key cytochr...