Is the efflux pump inhibitor Verapamil a potential booster for isoniazid against Mycobacterium tuberculosis?

• Main Authors: Renata Claro Ribeiro do Amaral (Author), Katiany Rizzieri Caleffi-Ferracioli (Author), Fernanda de Oliveira Demitto (Author), Aryadne Larissa de Almeida (Author), Vera Lucia Dias Siqueira (Author), Regiane Bertin de Lima Scodro (Author), Clarice Queico Fujimura Leite (Author), Fernando Rogério Pavan (Author), Rosilene Fressatti Cardoso (Author)
• Format: Book
• Published: Universidade de São Paulo, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The membrane-based efflux pump systems are recognized to have an important role in pathogenicity and drug resistance in Mycobacterium tuberculosis by the extrusion of toxic substrates and drugs from the inner bacillus. This study aimed to investigate the in vitro interaction of Verapamil (VP), an ef...