Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response

• Main Authors: Emilia Alors-Pérez (Author), Sergio Pedraza-Arevalo (Author), Ricardo Blázquez-Encinas (Author), Víctor García-Vioque (Author), Antonio Agraz-Doblas (Author), Elena M. Yubero-Serrano (Author), Marina E. Sánchez-Frías (Author), Raquel Serrano-Blanch (Author), María Ángeles Gálvez-Moreno (Author), Francisco Gracia-Navarro (Author), Manuel D. Gahete (Author), Álvaro Arjona-Sánchez (Author), Raúl M. Luque (Author), Alejandro Ibáñez-Costa (Author), Justo P. Castaño (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of tumors with growing incidence. Recent molecular analyses provided a precise picture of their genomic and epigenomic landscape. Splicing dysregulation is increasingly regarded as a novel cancer hallmark influencing key tumor...