An in Vitro Assay of hERG K+ Channel Potency for a New EGFR Inhibitor FHND004

• Main Authors: Tao Jin (Author), Bingxue Hu (Author), Shanshan Chen (Author), Qiang Wang (Author), Xue Dong (Author), Yin Zhang (Author), Yongqiang Zhu (Author), Zhao Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

FHND004 is a newly synthesized epidermal growth factor receptor (EGFR) inhibitor for the treatment of non-small cell lung cancer (NSCLC). The aim of the present study was to investigate the impacts of FHND004 on human ether-à-go-go-related gene (hERG) K+ channels and the molecular mechanisms underly...