Utilizing RNA nanotechnology to construct negatively charged and ultrasound-responsive nanodroplets for targeted delivery of siRNA

• Main Authors: Lu Guo (Author), Dandan Shi (Author), Mengmeng Shang (Author), Xiao Sun (Author), Dong Meng (Author), Xinxin Liu (Author), Xiaoying Zhou (Author), Jie Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ultrasound nanodroplets (NDs) have been reported as a promising nanocarrier for siRNA delivery depending on its unique strengths of sonoporation. Presently, common means for NDs-mediated siRNA delivery is through electrostatic interaction, but challenges like cationic toxicity still exist. In this s...