Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitis

• Main Authors: Qingqing Feng (Author), Yuanqiang Li (Author), Hongli Zhang (Author), Ziwei Wang (Author), Xiaobo Nie (Author), Denglin Yao (Author), Lu Han (Author), Wei-Dong Chen (Author), Yan-Dong Wang (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic predisposition and disruption of host gut microbiota and immune system can result in inflammatory bowel disease (IBD). Here, we show that miRNA-149-5p (miR-149-5p) and miRNA-149-3p (miR-149-3p) play crucial roles in IBD. Mice lacking miR-149-3p were considerably more susceptible to dextran s...