The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome

• Egile Nagusiak: Balbino Lino dos Santos (Egilea), Cleonice Creusa dos Santos (Egilea), Janaina R. P. Soares (Egilea), Karina C. da Silva (Egilea), Juciele Valeria R. de Oliveira (Egilea), Gabriele S. Pereira (Egilea), Fillipe M. de Araújo (Egilea), Maria de Fátima D. Costa (Egilea), Jorge Mauricio David (Egilea), Victor Diogenes A. da Silva (Egilea), Arthur Morgan Butt (Egilea), Silvia Lima Costa (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Agathisflavone, purified from <i>Cenostigma pyramidale</i> (Tul.) has been shown to be neuroprotective in in vitro models of glutamate-induced excitotoxicity and inflammatory damage. However, the potential role of microglial regulation by agathisflavone in these neuroprotective effects i...