Targeting mitochondrial metabolism with CPI-613 in chemoresistant ovarian tumors

• Main Authors: Mary P. Udumula (Author), Faraz Rashid (Author), Harshit Singh (Author), Tim Pardee (Author), Sanjeev Luther (Author), Tanya Bhardwaj (Author), Km Anjaly (Author), Sofia Piloni (Author), Miriana Hijaz (Author), Radhika Gogoi (Author), Philip A. Philip (Author), Adnan R. Munkarah (Author), Shailendra Giri (Author), Ramandeep Rattan (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background There is evidence indicating that chemoresistance in tumor cells is mediated by the reconfiguration of the tricarboxylic acid cycle, leading to heightened mitochondrial activity and oxidative phosphorylation (OXPHOS). Previously, we have shown that ovarian cancer cells that are r...