Determining the Oxidation Mechanism through Radical Intermediates in Polysorbates 80 and 20 by Electron Paramagnetic Resonance Spectroscopy

• Autori principali: Adam T. Sutton (Autore), Richard R. Rustandi (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2024-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Polysorbates 20 and 80 (PS20 and PS80) are added to many commercial biologic and vaccine pharmaceuticals. It is commonly known that these polysorbates undergo a radical oxidation mechanism; however, the identity of these radical intermediates has not been clearly determined. Furthermore, PS20 and PS...