Immune protection against Trypanosoma cruzi induced by TcVac4 in a canine model.

• Main Authors: José E Aparicio-Burgos (Author), José A Zepeda-Escobar (Author), Roberto Montes de Oca-Jimenez (Author), José G Estrada-Franco (Author), Alberto Barbabosa-Pliego (Author), Laucel Ochoa-García (Author), Ricardo Alejandre-Aguilar (Author), Nancy Rivas (Author), Giovanna Peñuelas-Rivas (Author), Margarita Val-Arreola (Author), Shivali Gupta (Author), Felix Salazar-García (Author), Nisha J Garg (Author), Juan C Vázquez-Chagoyán (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease, caused by Trypanosoma cruzi, is endemic in southern parts of the American continent. Herein, we have tested the protective efficacy of a DNA-prime/T. rangeli-boost (TcVac4) vaccine in a dog (Canis familiaris) model. Dogs were immunized with two-doses of DNA vaccine (pcDNA3.1 encoding...